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3 minutes ago, mariokempes56 said:

Interesting read.Ā  Questions are..is she right,Ā  are the facts right? Why haven't others picked these up ?

Need more info. Could just be companies now vying for the market as options out there and the oxford one is cheapest and easiest to distribute.

It's a pain in the arse being ignorant and pretty thick with this stuff, hard for me to make decisions on what is happening.

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27 minutes ago, phart said:

Need more info. Could just be companies now vying for the market as options out there and the oxford one is cheapest and easiest to distribute.

It's a pain in the arse being ignorant and pretty thick with this stuff, hard for me to make decisions on what is happening.

Not being ignorant at all mate. Unless this area was your specialism its pretty impossible to get the true picture.Ā  I knew you read more than most so thought I'd ask.

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Sounds like the Oxford/Zeneca clinical trials haven't been as rigorous or as well organised as the as the other two vaccines which have been making the headlines (Pfizer/BioNtech and Moderna). This possibly means that the Oxford one will have less chance of being approved by the FDA for use in the USA. That doesn't mean it won't be approved for use elsewhere based on the current phase 3 trial data. Different regulatory authorities have different criteria for approval. My gut feeling is that the half dose issue will take a bit of explaining and may lead to further trials being required before approval is given. But I'm just guessing. The main thing to remember is that no vaccine is available for general use until approval has been given. Lots of new medical treatments fall at the last hurdle and never get approval. This is bound to happen with at least some of the COVID19 vaccines currently being developed. There are hundreds of vaccines in development currently. One of the ones I've been reading about is the Janssen one which seems to be flying under the radar a wee bit.Ā 

All these interim announcements we have been getting, before the phase 3 trials have even been completed, are mainly for marketing and status purposes.Ā 

Another thing about the Oxford one is that the developers have always said that they want it to be cheap and freely available on a not for profit basis. They may not even be targeting the USA market and may never go for FDA approval. Although, getting FDA approval is often seen as the best way to get into other markets. I would image AstraZeneca will be handling that side of it.Ā 

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This article gives a wee insight into one of the many ethical dilemmas surrounding the fast tracking of the approval for these vaccines.Ā 

https://www.nature.com/articles/d41586-020-03219-y

The FDA are due to meet to discuss the Moderna and BioNtech vaccines on 10th December, soĀ news reports about potential widespread use before xmas may be a bit wide of the mark?Ā 

One other thing to consider is that both of these vaccines have been partially funded by the US Government's Operation Warp Speed. I think (but I could be wrong on this) this means that the US GovernmentĀ have effectively bought up the first 100 million doses produced of each of those vaccines.

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The coverage of the Oxford vaccine on the BBC seemed a bit slanted towards the "It has a British connection so let's hype it up as world-beating".Ā  However the 70% figure seems to me to be a lot less than the figures in the 90%+ region that were quoted for the other vaccines.Ā  I know which one IĀ want.Ā  Right through the pandemic we've heard UK govt ministers describing thins as world beating.Ā  Personally I think things that work properly are a better bet than the UK govt's idea of word beating things.

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34 minutes ago, Alibi said:

The coverage of the Oxford vaccine on the BBC seemed a bit slanted towards the "It has a British connection so let's hype it up as world-beating".Ā  However the 70% figure seems to me to be a lot less than the figures in the 90%+ region that were quoted for the other vaccines.Ā  I know which one IĀ want.Ā  Right through the pandemic we've heard UK govt ministers describing thins as world beating.Ā  Personally I think things that work properly are a better bet than the UK govt's idea of word beating things.

It might also have something to do with the fact that the UK gov ordered 100 million doses of the Oxford/Pfizer vaccine? There is a lot of politics going on. Which vaccine we, as individuals,Ā eventually get offered will be dependent on a lot of different factors.

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Ā 

Ā 

This is a list of the vaccines which have currently been pre ordered by the UK government. Of course, all of these are dependent on passing the regulatory requirements of the MHRA.

BioNTech/Pfizer for 40 million doses

Oxford/AstraZeneca for 100 million doses

Moderna for 5 million doses

GlaxoSmithKline and Sanofi Pasteur for 60 million doses

Novavax for 60 million doses

Janssen for 30 million doses

Valneva for 60 million doses

So far, I think the BioNtech one is the only one which has been formally submitted to the MHRA. But the MHRAĀ will also be looking very closely at all the interim results which are being published for all the other possible vaccine candidates. I don't think Oxford/AstraZeneca areĀ ready to formally submit their results just yet.Ā 

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23 hours ago, mariokempes56 said:

Interesting read.Ā  Questions are..is she right,Ā  are the facts right? Why haven't others picked these up ?

Just heard on the news that the Oxford/AstraZeneca data is due to be published next week. So we a can all read it ourselves and make up our own minds.Ā ;)

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AstraZeneca/OxfordĀ have announced a new phase 3 trial based on the lower first dose. This might delay things a wee bit but it will depend on the MHRA. There may be enough data in the original trial to allow them to approve it? There is some talk that the less effective vaccines may be given to younger folk who are less at risk, and the more effective ones given to the more vulnerable. Which might mean younger folk get offered a vaccine first.Ā A lot will depend on which ones get approved and the timing of that approval. Too early to say yet.

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2 hours ago, Orraloon said:

AstraZeneca/OxfordĀ have announced a new phase 3 trial based on the lower first dose. This might delay things a wee bit but it will depend on the MHRA. There may be enough data in the original trial to allow them to approve it? There is some talk that the less effective vaccines may be given to younger folk who are less at risk, and the more effective ones given to the more vulnerable. Which might mean younger folk get offered a vaccine first.Ā A lot will depend on which ones get approved and the timing of that approval. Too early to say yet.

Makes sense.Ā  Young are the most likely spreaders as well.Ā Ā 

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Everything trending down which is good, Moderna vaccine looking really good as well, from what I can tell reading the stuff about it.

Sort of watching the USA in a bit of despair as we see what happens in the next two weeks after thanksgiving where they just had 50 million folk traveling all over the place. Hopefully we don't get a huge uptick over Christmas with everyone just reverting back to normal behaviour.

Then we can move onto the shitshow that will be Brexit then the next few decades dominated by global warming which will dwarf both previous problems.

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59 minutes ago, phart said:

Everything trending down which is good, Moderna vaccine looking really good as well, from what I can tell reading the stuff about it.

Sort of watching the USA in a bit of despair as we see what happens in the next two weeks after thanksgiving where they just had 50 million folk traveling all over the place. Hopefully we don't get a huge uptick over Christmas with everyone just reverting back to normal behaviour.

Then we can move onto the shitshow that will be Brexit then the next few decades dominated by global warming which will dwarf both previous problems.

You are sounding awfy like Private Frazer.Ā :lol:

Lighten up, we've qualified for the EUROs.

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2 hours ago, phart said:

Everything trending down which is good, Moderna vaccine looking really good as well, from what I can tell reading the stuff about it.

Ā 

I've just noticed the final report for their phase 3 trials seems to suggest it could be even better than the interim report suggested. Pity the UK has only ordered 7 million doses of this one.

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1 hour ago, King Of Paisley said:

Pfizer vaccine approved for use in the U.K. Breaking story on the Beeb website

Good news. I think the UK is due to get the first 800,000 dose early next week but the next delivery won't be until just after new year. That's enough forĀ 400,000 people. I would assume that a proportion of that will be coming to Scotland. This is more exciting than trying to work out how many points we will need for anĀ England Scotland ticket. Me, being a relative youngster, I'm guessing around February for my first dose. And probably get the slightly inferior Oxford variety.Ā :lol:

Ā 

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34 minutes ago, Orraloon said:

Good news. I think the UK is due to get the first 800,000 dose early next week but the next delivery won't be until just after new year. That's enough forĀ 400,000 people. I would assume that a proportion of that will be coming to Scotland. This is more exciting than trying to work out how many points we will need for anĀ England Scotland ticket. Me, being a relative youngster, I'm guessing around February for my first dose. And probably get the slightly inferior Oxford variety.Ā :lol:

Ā 

I will let you know how it goes. I'm an old sod, work in the care sector and i have underlying health conditions.:spin:

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20 hours ago, Orraloon said:

You are sounding awfy like Private Frazer.Ā :lol:

Lighten up, we've qualified for the EUROs.

Trust me it's not looking good at all. Like Coronavirus nothing will be done till it starts affecting folk and by then it will be too late. Next 100 years going to be a total shitshow as the enviroment changes rapidly.

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58 minutes ago, wee-toon-red said:

First vaccinationsĀ in Scotland scheduled for Tuesday next week. That's impressively quick.

The systems have been in place for administering the vaccine for a while now. That bit should be relatively straight forward. For example, theĀ flu vaccines will be administered to over two million people in Scotland this winter. The hard bit is going to be getting enough doses of the COVID vaccines in as short a time as possible. I think Scotland will get enough of the Pfizer vaccine to vaccinate about 35,000 people before the end of 2020. Those doses will be used up pretty quickly. To make a big difference quickly we really need the Oxford/AstraZeneca one to be approved as well. Hopefully the MHRA now have enough data to do this.

Ā 

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